Indigenous and independent origin of the B*-mutation in ancient India: Is it a myth or reality?
Identifieur interne : 001512 ( Main/Exploration ); précédent : 001511; suivant : 001513Indigenous and independent origin of the B*-mutation in ancient India: Is it a myth or reality?
Auteurs : R. S. Balgir [Inde]Source :
- Mankind quarterly [ 0025-2344 ] ; 2001.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Inde.
- topic : Répartition géographique, Migration.
English descriptors
- KwdEn :
Abstract
The sickle cell anemia is one of the major genetic and public health problems not only in India but also throughout the world. The origin and dispersal of B*-mutation is, still a controversial issue in the world including in India. Different views have been expressed by several investigators, varying from a single independent mutation to multiple mutations at several occasions, from a single geographical location to multicentric origin(s), from diffusion to large scale migrations and altogether independent B*-mutation in the world. Several B*-mutations namely, Senegal, Benin, Bantu, Cameroon and Arab-Indian have been identified. The later B*-mutation has been encountered in East Saudi Arabian peninsula and India. Recent studies in India question the independent Asian origin of B*-mutation and also of the unicentric origin of the tribal populations in India. Evidence from Indus Valley Civilization remains indicates the existence of sickle cell anemia even before the Muslim expansions took place in India. This further testifies the movements and migrations of the people from different parts of the world including from Africa to India during ancient times. The probability of migration of B*-mutation from Africa to India is not ruled out because of several African B*-haplotypes prevalent in India. Further, the possible explanation for the spread of B*-mutation in India is discussed.
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Le document en format XML
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S." last="Balgir">R. S. Balgir</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Regional Medical Research Center (ICMR)</s1><s2>Chandrasekharpur</s2><s3>IND</s3><sZ>1 aut.</sZ></inist:fA14><country>Inde</country><wicri:noRegion>Regional Medical Research Center (ICMR)</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Mankind quarterly</title><title level="j" type="abbreviated">Mank. q.</title><idno type="ISSN">0025-2344</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Mankind quarterly</title><title level="j" type="abbreviated">Mank. q.</title><idno type="ISSN">0025-2344</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anaemia</term><term>Caste</term><term>Ethnicity</term><term>Genetic Pathology</term><term>Geographical diffusion</term><term>Geographical distribution</term><term>India</term><term>Migration</term><term>Mutation</term><term>Origin</term><term>Paleopathology</term><term>South Asia</term><term>Tribal society</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Asie méridionale</term><term>Inde</term><term>Maladie génétique</term><term>Mutation</term><term>Ethnicité</term><term>Société tribale</term><term>Caste</term><term>Origine</term><term>Diffusion géographique</term><term>Répartition géographique</term><term>Migration</term><term>Anémie</term><term>Paléopathologie</term><term>Harappa</term><term>Drépanocytose</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Répartition géographique</term><term>Migration</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The sickle cell anemia is one of the major genetic and public health problems not only in India but also throughout the world. The origin and dispersal of B<sup>*</sup>-mutation is, still a controversial issue in the world including in India. Different views have been expressed by several investigators, varying from a single independent mutation to multiple mutations at several occasions, from a single geographical location to multicentric origin(s), from diffusion to large scale migrations and altogether independent B<sup>*</sup>-mutation in the world. Several B<sup>*</sup>-mutations namely, Senegal, Benin, Bantu, Cameroon and Arab-Indian have been identified. The later B<sup>*</sup>-mutation has been encountered in East Saudi Arabian peninsula and India. Recent studies in India question the independent Asian origin of B<sup>*</sup>-mutation and also of the unicentric origin of the tribal populations in India. Evidence from Indus Valley Civilization remains indicates the existence of sickle cell anemia even before the Muslim expansions took place in India. This further testifies the movements and migrations of the people from different parts of the world including from Africa to India during ancient times. The probability of migration of B<sup>*</sup>-mutation from Africa to India is not ruled out because of several African B<sup>*</sup>-haplotypes prevalent in India. Further, the possible explanation for the spread of B<sup>*</sup>-mutation in India is discussed.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Balgir, R S" sort="Balgir, R S" uniqKey="Balgir R" first="R. S." last="Balgir">R. S. Balgir</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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